Document Detail

Humoral reactions in syngeneic hosts against tumor cell surface incomplete saccharide moieties.
MedLine Citation:
PMID:  947853     Owner:  NLM     Status:  MEDLINE    
Components on the surface of MM2 ascites mammary carcinoma cells induce agglutination factors in the serum of syngeneic host C3H/He mice, and bind the factors in vitro. These components have been classified into three groups: MM2-specific substances, mammary tumor virus (MTV)-associated substances and tumor-associated embryonic materials. The substances contained saccharide moieties and their terminal sugar residues were essential for the binding of the serum factors. These terminal saccharides were exposed during cell proliferation,but masked in stationary cells, at least partly, due to elongation of the saccahride moieits. The terminal structures of these polysaccharide moities of growing and stationary cells were studied by semiquantitative tumor cell agglutination using the agglutinating activities against MM2 cells of MM2-regressor serum and of FMA/R- and Ehrlich-regressor sera which had partial cross-agglutination activities. Agglutination by phytohemagglutinins, inhibition of the agglutination by saccharides or with isolated cell surface components and treatment of the cells with glycosidases were also used for this purpose.
T Tanino; K Egawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  17     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1976 Jun 
Date Detail:
Created Date:  1976-10-01     Completed Date:  1976-10-01     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  730-5     Citation Subset:  IM    
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MeSH Terms
Agglutination / drug effects
Agglutination Tests
Antibodies, Neoplasm*
Antibody Formation*
Antigens, Neoplasm / analysis
Binding Sites, Antibody
Cell Line
Cell Membrane / immunology*
Glycoside Hydrolases / pharmacology
Mammary Neoplasms, Experimental / immunology*
Mice, Inbred C3H
Neoplasm Transplantation
Polysaccharides / immunology
Protein Binding / drug effects
Sialic Acids / pharmacology
Transplantation, Isogeneic
Reg. No./Substance:
0/Antibodies, Neoplasm; 0/Antigens, Neoplasm; 0/Binding Sites, Antibody; 0/Lectins; 0/Polysaccharides; 0/Sialic Acids; EC 3.2.1.-/Glycoside Hydrolases

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