Document Detail


Humoral immune responses in human loaiasis.
MedLine Citation:
PMID:  6965043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some immunological parameters in three white patients who contracted loaiasis in endemic areas are reported. Microfilariae count in peripheral blood was elevated in one patient, discrete in another while in the third no microfilariae were detected. Serum IgE levels were elevated in two patients and normal in one of them. High eosinophils percentage (greater than 30%) and high titres of specific anti-filarial antibodies were detected in all patients. C3 and C4 levels fell between the normal values and C3PA was low in one patient. No circulating immune complexes were demonstrated. Two patients showed high anticomplementary activity. Our results are in accord with the possibility of a suppression mechanism in immune response in patients with high microfilaremia. Clinical features of loaiasis could be related to a type 1 (reaginic) reaction.
Authors:
G Orlando; M Galli; A Lazzarin; G Serino; C Inzoli; G Calello; M Almaviva
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bollettino dell'Istituto sieroterapico milanese     Volume:  61     ISSN:  0021-2547     ISO Abbreviation:  Boll Ist Sieroter Milan     Publication Date:  1982  
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  17720040R     Medline TA:  Boll Ist Sieroter Milan     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  258-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibody Formation
Complement C3 / analysis
Complement C4 / analysis
Filariasis / immunology*
Humans
Immunoglobulin E / analysis
Loiasis / immunology*
Middle Aged
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 37341-29-0/Immunoglobulin E

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