Document Detail

Humoral immune responses in foetal sheep.
MedLine Citation:
PMID:  711249     Owner:  NLM     Status:  MEDLINE    
A total of fifty-two foetal sheep between 49 and 126 days gestation were injected with polymeric and monomeric flagellin, dinitrophenylated monomeric flagellin, chicken red blood cells, ovalbumin, ferritin, chicken gamma-globulin and the somatic antigens of Salmonella typhimurium in a variety of combinations. Immune responses were followed in these animals by taking serial blood samples from them through indwelling vascular cannulae and measuring the circulating titres of antibody. Of the antigens tested, ferritin induced immune responses in the youngest foetuses. A short time later in gestation, the majority of foetuses responded to chicken red blood cells, polymeric flagellin, monomeric flagellin and dinitrophenylated monomeric flagellin. Only older foetuses responded regularly to chicken gamma-globulin and ovalbumin. However, antibodies to all these antigens were first detected over the relatively short period of development between 64 and 82 days gestation and this made it difficult to define any precise order in the development of immune responsiveness. Of the antigens tested only the somatic antigens of S. typhimurium failed to induce a primary antibody response during foetal life. The character and magnitude of the antibody responses in foetuses changed throughout in utero development. Both the total amount of antibody produced and the duration of the response increased with foetal age. Foetuses younger than 87 days gestation did not synthesize 2-mercaptoethanol resistant antibodies or IgG1 immunoglobulin to any of the antigens tested, whereas most foetuses older than this regularly did so.
K J Fahey; B Morris
Related Documents :
7047249 - Increase in the number of splenic plaque forming cells with length of gestation in untr...
342399 - Suppression of primary immune response by heterologous anti-lymphocyte sera.
3510099 - Cells involved in the immune response. xxxi. the role of the spleen in the primary and ...
3818259 - Direct suppression of antibody responses by chlorinated dibenzodioxins in cultured sple...
2235829 - Immune responsiveness of neonatal chicks and immunocyte precursors from unprimed juveni...
1675499 - Human immunosuppression induced by sea nettle (chrysaora quinquecirrha) venom.
12534549 - Allergen-specific conventional immunotherapy decreases immunoglobulin e-mediated basoph...
3098699 - Serological cross-reactions between rickettsia typhi, proteus vulgaris ox19, and legion...
9033639 - The expression of mouse gene p1a in testis does not prevent safe induction of cytolytic...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunology     Volume:  35     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-01-24     Completed Date:  1979-01-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  651-61     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animals, Newborn / immunology
Antibody Formation*
Fetal Blood / immunology*
Gestational Age
Hemagglutination Tests
Immunoglobulins / biosynthesis
Sheep / embryology*,  immunology
Reg. No./Substance:
0/Antigens; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Partial trisomy for the short arm of chromosome 2 due to familial balance translocation.
Next Document:  Correlation between intestinal synthesis of specific immunoglobulin A and protection against experim...