Document Detail

Humoral immune responses of cats to feline infectious peritonitis virus infection.
MedLine Citation:
PMID:  1322714     Owner:  NLM     Status:  MEDLINE    
Immunoperoxidase antibody (IPA) method as a titrating method of feline infectious peritonitis (FIP) virus (FIPV) was developed for titrating antibody to FIPV (IPA-titer). By this method the immune responses of the cats that had been infected with FIPV, were traced. The infected cats could be grouped into three types by their immune response to FIPV and clinical appearances. Type I cats lived for a long time, formed a major group among infected cats, had 160 to 1 x 10(4) IPA-titers, and showed healthy appearances without any changes both on autopsy and histopathologically. From among type I cats, type II cats appeared sporadically with rapid elevation of IPA titers to 3.2 x 10(5) and showing clinical signs of FIP, and died. Type III cats lived healthily for a long time with gradual elevation of IPA-titers to a plateau of about 1 x 10(5), then showed neuronal disorder of hind leg paralysis with the descending IPA-titers to 2 x 10(4), and died. Thus, typical FIP appeared as a hyper-immune disease. Other related problems are discussed.
K Kai; M Yukimune; T Murata; Y Uzuka; M Kanoe; H Matsumoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  54     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-09-04     Completed Date:  1992-09-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  501-7     Citation Subset:  IM    
Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, Japan.
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MeSH Terms
Antibodies, Viral / biosynthesis*,  blood
Coronavirus, Feline / immunology*
Feline Infectious Peritonitis / immunology*
Immunoenzyme Techniques
Immunoglobulin G / blood
Neutralization Tests
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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