Document Detail

Humoral hypercalcemia of malignancy due to bipartite squamous cell/small cell carcinoma of the esophagus immunoreactive for parathyroid hormone related protein.
MedLine Citation:
PMID:  14641300     Owner:  NLM     Status:  MEDLINE    
We report the case of a 63-year-old man who presented with weakness, fatigue, dehydration, confusion, abdominal pain, congestive heart failure and hypercalcemia. He expired and autopsy revealed an exulcerating carcinoma of the esophagus, invading the esophageal wall and metastasizing to the lungs, skin and lymph nodes. Histology demonstrated an epithelial tumor consisting of two components with transition between the two. One component was a keratinizing squamous cell carcinoma, whereas the other component consisted of pleomorphic small cells. The hypercalcemia was assumed to be due to parathyroid hormone related protein (PHRP), which was demonstrated by immunohistochemistry only in the pleomorphic small cells and not in the squamous cells. PHRP induced humoral hypercalcemia of malignancy is most often associated with squamous cell carcinomas. The finding that in our case, the pleomorphic small cell component was PHRP immunopositive and the squamous cell component showed no immunoreactivity, is intriguing and remains unexplained.
F Fereidooni; E Horvath; K Kovacs
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E     Volume:  16     ISSN:  1120-8694     ISO Abbreviation:  Dis. Esophagus     Publication Date:  2003  
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-05-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809160     Medline TA:  Dis Esophagus     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Carcinoma, Small Cell / chemistry*,  complications,  pathology
Carcinoma, Squamous Cell / chemistry*,  pathology
Esophageal Neoplasms / chemistry*,  complications,  pathology
Fatal Outcome
Hypercalcemia / etiology*
Middle Aged
Parathyroid Hormone-Related Protein / adverse effects,  analysis*
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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