Document Detail

Humoral factors determining the blood pressure response to converting enzyme inhibition and calcium channel blockade.
MedLine Citation:
PMID:  2222951     Owner:  NLM     Status:  MEDLINE    
Renin and catecholamine levels were determined in patients with mild to moderate hypertension before and after treatment with sustained release diltiazem or captopril and were correlated with the blood pressure response to these antihypertensives. Eight weeks of treatment with either agent led to equal decreases in both systolic and diastolic blood pressure. Pretreatment plasma renin activity (PRA) and plasma norepinephrine did not predict the blood pressure response to either agent. Diltiazem significantly increased both PRA and supine norepinephrine levels. However, in the diltiazem treated patients, there was no correlation between the change in plasma norepinephrine and the change in systolic or diastolic blood pressure. In contrast, there was a negative correlation (P less than .05) between the reactive rise in PRA and the decrease in systolic blood pressure. Thus, the antihypertensive response to a calcium channel blocker may be determined, in part, by the reactive response of pressor systems.
R R Evans; W R Davis; J M Wallace; D J DiPette; O B Holland
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  3     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-12-27     Completed Date:  1990-12-27     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  605-10     Citation Subset:  IM    
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77550.
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MeSH Terms
Blood Pressure / drug effects*
Captopril / therapeutic use*
Delayed-Action Preparations
Diltiazem / therapeutic use*
Epinephrine / blood*
Hypertension / blood,  drug therapy*
Middle Aged
Norepinephrine / blood*
Renin / blood*
Reg. No./Substance:
0/Delayed-Action Preparations; 42399-41-7/Diltiazem; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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