| Humoral effects of long-term oral enalapril therapy. | |
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MedLine Citation:
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PMID: 3010707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-seven subjects with essential hypertension were prospectively followed for a minimum of 100 weeks, receiving either enalapril monotherapy or enalapril and hydrochlorothiazide combination therapy. Blood pressure and the renin-angiotensin-aldosterone system were assessed following 4 weeks of placebo therapy, and 56 and 96 weeks of maintenance drug therapy. Blood pressure was well controlled with either form of therapy. Plasma renin activity remained stimulated following both long-term monotherapy and combination therapy. However, immunoreactive plasma angiotensin II concentration was not suppressed following either long-term monotherapy or combination therapy. Similarly, plasma aldosterone concentration was not suppressed following either form of therapy; indeed, combination therapy was associated with stimulation of plasma aldosterone concentration. We conclude that enalapril monotherapy or enalapril/hydrochlorothiazide therapy was effective in controlling blood pressure, but that long-term blood pressure control must be related to an angiotensin II independent antihypertensive mechanism. |
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Authors:
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G P Reams; J H Bauer |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 7 ISSN: 0272-6386 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1986 May |
Date Detail:
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Created Date: 1986-06-10 Completed Date: 1986-06-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 402-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aldosterone / blood Angiotensin II / blood Blood Pressure / drug effects* Blood Specimen Collection / methods Clinical Trials as Topic Drug Therapy, Combination Enalapril / administration & dosage* Humans Hydrochlorothiazide / administration & dosage Hypertension / drug therapy Longitudinal Studies Potassium / blood Pulse / drug effects Random Allocation Renin / blood Renin-Angiotensin System / drug effects* |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 58-93-5/Hydrochlorothiazide; 7440-09-7/Potassium; 75847-73-3/Enalapril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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