| Humoral effect of norepinephrine on renin release in humans. | |
| | |
MedLine Citation:
|
PMID: 2679773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We compared the effects of infused norepinephrine (NE) to another alpha-adrenergic agonist, phenylephrine, in order to understand better the influence of circulating NE on plasma renin activity (PRA) in man. In matched groups of normotensive men, NE (80 ng/min/kg) or phenylephrine (800 ng/min/kg) raised blood pressure by 15 to 20 mm Hg and caused reflex decreases in heart rate of 8 to 10 beats per minute. Infused phenylephrine suppressed PRA by about 15%, whereas NE increased PRA by about 40% (P less than .02). This differential effect of alpha-agonists on PRA defines an important humoral effect of NE, which should be considered to be a "cardiovascular hormone." |
| | |
Authors:
|
M R Licht; J L Izzo |
Related Documents
:
|
9931123 - Appropriate regulation of renin and blood pressure in 45-kb human renin/human angiotens... 2220603 - Neuroendocrine activity in congestive heart failure. 6202633 - Hemodynamic effects of chronic alteration in hematocrit in spontaneously hypertensive r... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of hypertension Volume: 2 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1989 Oct |
Date Detail:
|
Created Date: 1989-11-28 Completed Date: 1989-11-28 Revised Date: 2009-02-24 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 788-91 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Rochester Medical Center, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Pressure
/
drug effects Heart Rate / drug effects Humans Infusions, Intravenous Norepinephrine / pharmacology* Phenylephrine / pharmacology Renin / blood* |
| Grant Support | |
ID/Acronym/Agency:
|
RR 00044/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
51-41-2/Norepinephrine; 59-42-7/Phenylephrine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incorporation of labeled renin into the tissues of the rabbit.
Next Document: Effect of age on left ventricular filling in children of hypertensive parents.