Document Detail

Humoral effect of norepinephrine on renin release in humans.
MedLine Citation:
PMID:  2679773     Owner:  NLM     Status:  MEDLINE    
We compared the effects of infused norepinephrine (NE) to another alpha-adrenergic agonist, phenylephrine, in order to understand better the influence of circulating NE on plasma renin activity (PRA) in man. In matched groups of normotensive men, NE (80 ng/min/kg) or phenylephrine (800 ng/min/kg) raised blood pressure by 15 to 20 mm Hg and caused reflex decreases in heart rate of 8 to 10 beats per minute. Infused phenylephrine suppressed PRA by about 15%, whereas NE increased PRA by about 40% (P less than .02). This differential effect of alpha-agonists on PRA defines an important humoral effect of NE, which should be considered to be a "cardiovascular hormone."
M R Licht; J L Izzo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  2     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-28     Completed Date:  1989-11-28     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  788-91     Citation Subset:  IM    
Department of Medicine, University of Rochester Medical Center, New York.
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MeSH Terms
Blood Pressure / drug effects
Heart Rate / drug effects
Infusions, Intravenous
Norepinephrine / pharmacology*
Phenylephrine / pharmacology
Renin / blood*
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 59-42-7/Phenylephrine; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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