Document Detail


Humoral and cellular parameters of the immune system of Cebus apella monkeys. Cross reactivity between monkey and human immunoglobulins.
MedLine Citation:
PMID:  3150887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The humoral and cellular immunological parameters of the New World non-human primate Cebus apella were analysed. The study included: serum protein immunoelectrophoretic analysis; cross reactivity between monkey and human immunoglobulins by immunoprecipitation, ELISA and indirect immunofluorescence tests; immunoglobulin quantitation by radial immunodiffusion; and assays with peripheral blood lymphocytes involving tests for E and EAC rosettes and detection of surface markers (surface immunoglobulins and CD4-CD8 antigens). The results obtained showed that (a) at least three immunoglobulins with electrophoretic mobility corresponding to IgG, IgA and IgM which showed cross reactivity with the human ones were present in serum; (b) it was possible to evaluate the relative monkey immunoglobulin concentration using specific antibodies against human immunoglobulins and to obtain absolute values using adequate conversion factors; (c) lymphocytes forming E and EAC rosettes were found in peripheral blood in a similar proportion to that reported in man; (d) lymphocyte surface immunoglobulins were detected using anti-human immunoglobulin serum; (e) it was not possible to demonstrate the presence of T helper and T suppressor/cytotoxic lymphocytes using OK T4 and OK T8 monoclonal antibodies.
Authors:
K E de Palmero; C H Carbonetto; E L Malchiodi; R A Margni; C A Falasca
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  19     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-08-01     Completed Date:  1989-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  341-9     Citation Subset:  IM    
Affiliation:
Instituto Latinoamericano de Investigaciones Médicas, Universidad del Salvador (ILAIMUS), Facultad de Medicina, Universidad del Salvador, Buenos Aires.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cebidae / immunology*
Cebus / immunology*
Chagas Disease / immunology
Cross Reactions
Female
Humans
Immunity, Cellular
Immunoglobulins / immunology*
Lymphocytes / immunology
Male
Species Specificity
Chemical
Reg. No./Substance:
0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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