Document Detail

Humoral and cell-mediated autoimmunity in lichen sclerosus.
MedLine Citation:
PMID:  23301780     Owner:  NLM     Status:  Publisher    
We read with great interest the paper of Edmonds et al. (1) who observed that men with penile lichen sclerosus (PLS) have significantly increased extracellular matrix protein 1 (ECM1) serum levels when compared to healthy controls (HC). Similar results were previously found in women with vulvar LS (VLS).(2) Edmonds et al. 1 postulated that anti-ECM1 antibodies are not the causative mechanism but present an epiphenomenon in LS. Nevertheless, there is evidence for humoral as well as cell-mediated autoimmunopathogenic mechanisms driving LS.(1-5).
T Gambichler; D Belz; S Terras; A Kreuter
Publication Detail:
Type:  LETTER     Date:  2013-1-10
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
©The Authors bjd © 2013 British Association of Dermatologists.
Department of Dermatology, Ruhr-University Bochum, Bochum, Germany.
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