| Humoral immune response against P2β from Trypanosoma cruzi in persons with chronic Chagas disease: its relationship with treatment against parasites and myocardial damage. | |
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MedLine Citation:
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PMID: 21460013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection. |
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Authors:
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Diana L Fabbro; Verónica Olivera; Maria Laura Bizai; Susana Denner; Cristina Diez; Iván Marcipar; Iván Mancipar; Mirtha Streiger; Enrique Arias; Mónica del Barco; Diego Mendicino; Oscar Bottasso |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 84 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-06-07 Revised Date: 2012-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 575-80 Citation Subset: AIM; IM |
Affiliation:
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Centro de Investigaciones Sobre Endemias Nacionales, Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina. dfabbro@fbcb.unl.edu.ar |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Protozoan Cardiomyopathies / immunology Chagas Disease / immunology* Chronic Disease Female Humans Immunity, Humoral Male Nifurtimox / therapeutic use Nitroimidazoles / therapeutic use Protozoan Proteins / immunology* Ribosomal Proteins / immunology* Trypanocidal Agents / therapeutic use Trypanosoma cruzi / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Protozoan; 0/L12E protein, Trypanosoma cruzi; 0/Nitroimidazoles; 0/Protozoan Proteins; 0/Ribosomal Proteins; 0/Trypanocidal Agents; 22994-85-0/benzonidazole; 23256-30-6/Nifurtimox |
| Comments/Corrections | |
Erratum In:
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Am J Trop Med Hyg. 2012 Sep;87(3):582 Note: Mancipar, Iván [corrected to Marcipar, Iván] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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