Document Detail

Humidifier lung: possible contribution of endotoxin-induced lung injury.
MedLine Citation:
PMID:  12521211     Owner:  NLM     Status:  MEDLINE    
A 56-year-old man was admitted with cough, fever, myalgia, and arthralgia. Chest computed tomography demonstrated bilateral diffuse ground-glass opacities predominantly in the upper lungs. Subpleural non-segmental consolidation was observed in the late phase. Hypersensitivity pneumonitis was suspected, and an environmental provocation test with the incidental use of a home ultrasonic humidifier was positive. Unlike typical hypersensitivity pneumonitis, serum KL-6 levels were normal. Although several microorganisms were isolated from the humidifier water, there was no evidence for immune sensitization. We detected high amounts of endotoxin in the humidifier water, which may have contributed to the lung injury of this patient.
Hiroshi Ohnishi; Akihito Yokoyama; Hironobu Hamada; Seiko Manabe; Ryoji Ito; Akira Watanabe; Hitoshi Katayama; Yoshifumi Yasuhara; Junpei Ikezoe; Jitsuo Higaki
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  41     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-10     Completed Date:  2003-04-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1179-82     Citation Subset:  IM    
Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime.
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MeSH Terms
Alveolitis, Extrinsic Allergic / blood,  etiology*
Antigens / blood
Antigens, Neoplasm
Biological Markers / blood
Bronchoalveolar Lavage
CD4-CD8 Ratio
Endotoxins / adverse effects*
Glycoproteins / blood
Humidity / adverse effects*
Middle Aged
Tomography, X-Ray Computed
Reg. No./Substance:
0/Antigens; 0/Antigens, Neoplasm; 0/Biological Markers; 0/Endotoxins; 0/Glycoproteins; 0/MUC1 protein, human; 0/Mucin-1; 0/Mucins

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