| Humidifier lung: possible contribution of endotoxin-induced lung injury. | |
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MedLine Citation:
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PMID: 12521211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 56-year-old man was admitted with cough, fever, myalgia, and arthralgia. Chest computed tomography demonstrated bilateral diffuse ground-glass opacities predominantly in the upper lungs. Subpleural non-segmental consolidation was observed in the late phase. Hypersensitivity pneumonitis was suspected, and an environmental provocation test with the incidental use of a home ultrasonic humidifier was positive. Unlike typical hypersensitivity pneumonitis, serum KL-6 levels were normal. Although several microorganisms were isolated from the humidifier water, there was no evidence for immune sensitization. We detected high amounts of endotoxin in the humidifier water, which may have contributed to the lung injury of this patient. |
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Authors:
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Hiroshi Ohnishi; Akihito Yokoyama; Hironobu Hamada; Seiko Manabe; Ryoji Ito; Akira Watanabe; Hitoshi Katayama; Yoshifumi Yasuhara; Junpei Ikezoe; Jitsuo Higaki |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 41 ISSN: 0918-2918 ISO Abbreviation: Intern. Med. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-10 Completed Date: 2003-04-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 1179-82 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun, Ehime. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alveolitis, Extrinsic Allergic
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blood,
etiology* Antigens / blood Antigens, Neoplasm Biological Markers / blood Bronchoalveolar Lavage CD4-CD8 Ratio Endotoxins / adverse effects* Glycoproteins / blood Humans Humidity / adverse effects* Male Middle Aged Mucin-1 Mucins Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Antigens; 0/Antigens, Neoplasm; 0/Biological Markers; 0/Endotoxins; 0/Glycoproteins; 0/MUC1 protein, human; 0/Mucin-1; 0/Mucins |
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