Document Detail


Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
MedLine Citation:
PMID:  17332083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are many rodent models of autoimmune diabetes that have been used to study the pathogenesis of human type 1 diabetes (T1D), including the non-obese diabetic (NOD) mouse, the biobreeding (BB) rat, and the transgenic mouse models. However, mice and rats are not humans, and these rodent models do not completely recapitulate the autoimmune pathogenesis of the human disease. In addition, many of the reagents, tools, and therapeutics proposed for use in humans may be species specific and cannot be investigated in rodents. Researchers have used nonhuman primates to more closely mimic the human immune system and, to study species-specific therapeutics, but these studies are associated with additional ethical and economic constraints and, to date, no model of autoimmune diabetes in this species has been described. New animal models are needed that will permit the in vivo investigation of human immune systems and analyses of the pathogenesis of human T1D without putting individuals at risk. To fill this need, we are developing humanized mouse models for the in vivo study of T1D. These models are based on our newly generated stock of NOD-scid IL2rgamma(null) mice, which engraft at higher levels with human hematolymphoid cells and exhibit enhanced function of the engrafted human immune systems compared with previous humanized mouse models. Overall, development of these new generations of humanized mice should facilitate in vivo studies of the human immune system as well as permit the investigation of the pathogenesis and effector phases of human T1D.
Authors:
Leonard D Shultz; Todd Pearson; Marie King; Lisa Giassi; Lisa Carney; Bruce Gott; Bonnie Lyons; Aldo A Rossini; Dale L Greiner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-03-01
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1103     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-16     Completed Date:  2007-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-89     Citation Subset:  IM    
Affiliation:
Division of Diabetes, Department of Medicine, 373 Plantation Street, Biotech 2, Suite 218, Worcester, MA 01605, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Type 1 / genetics*,  immunology*
Disease Models, Animal
Humans
Interleukin Receptor Common gamma Subunit / deficiency
Mice
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
Reproducibility of Results
Chemical
Reg. No./Substance:
0/Interleukin Receptor Common gamma Subunit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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