| Humanized mice for immune system investigation: progress, promise and challenges. | |
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MedLine Citation:
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PMID: 23059428 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. These mouse strains support the engraftment of a functional human immune system and permit detailed analyses of human immune biology, development and functions. In this Review, we discuss recent advances in the development and utilization of humanized mice, the lessons learnt, the remaining challenges and the promise of using humanized mice for the in vivo study of human immunology. |
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Authors:
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Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
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Title: Nature reviews. Immunology Volume: - ISSN: 1474-1741 ISO Abbreviation: Nat. Rev. Immunol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101124169 Medline TA: Nat Rev Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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