Document Detail


Humanized mice for immune system investigation: progress, promise and challenges.
MedLine Citation:
PMID:  23059428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. These mouse strains support the engraftment of a functional human immune system and permit detailed analyses of human immune biology, development and functions. In this Review, we discuss recent advances in the development and utilization of humanized mice, the lessons learnt, the remaining challenges and the promise of using humanized mice for the in vivo study of human immunology.
Authors:
Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-12
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  12     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-25     Completed Date:  2013-01-04     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  786-98     Citation Subset:  IM    
Affiliation:
Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA. lds@jax.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Hematopoietic Stem Cell Transplantation
Humans
Immune System / physiology*
Interleukin Receptor Common gamma Subunit / genetics*
Mice
Mice, SCID* / genetics,  immunology
Mice, Transgenic
Grant Support
ID/Acronym/Agency:
AI073146/AI/NIAID NIH HHS; AI46629/AI/NIAID NIH HHS; CA034196/CA/NCI NIH HHS; DK092758/DK/NIDDK NIH HHS; DK32520/DK/NIDDK NIH HHS; R01 AI073146/AI/NIAID NIH HHS; UO1 DK089572/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Il2rg protein, mouse; 0/Interleukin Receptor Common gamma Subunit
Comments/Corrections

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