Document Detail


Human umbilical cord mesenchymal stem cells protect against ischemic brain injury in mouse by regulating peripheral immunoinflammation.
MedLine Citation:
PMID:  25449888     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Current treatments for ischemic stroke are limited, stem cell transplantation offers great potential as a therapeutic strategy. The present study was undertaken to determine whether human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) could improve brain injury after middle cerebral artery occlusion (MCAO) through modulating peripheral immunoinflammation. The study showed that neurological deficit was ameliorated and brain edema, infarct volume was significantly decreased from 72h to 1 week post-MCAO with hUC-MSCs treatment via tail vein injection within 30mins after stroke; hUC-MSCs attenuated the levels of inflammatory factors including IL-1, TNF-α, IL-23, IL-17 and IL-10 in peripheral blood serum and ischemia hemisphere after stroke; hUC-MSCs significantly decreased the level of Th17 cells at 24h and increased the level of Tregs at 72h post-MCAO in peripheral immune system; the level of TGF-β in blood serum was enhanced by hUC-MSCs. In conclusion, our findings suggested that hUC-MSCs had neuroprotection in MCAO mice by TGF-β modulating peripheral immune and hUC-MSCs may be as a potential therapy for ischemic stroke.
Authors:
Qiantao Cheng; Zhuo Zhang; Shenyang Zhang; Hui Yang; Xin Zhang; Jie Pan; Leihua Weng; Dujuan Sha; Min Zhu; Xiang Hu; Yun Xu
Related Documents :
8345188 - Specific v beta t cell subsets mediate the immediate hypersensitivity response to ragwe...
17906078 - Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin an...
25482558 - Sox2 acts in a dose-dependent fashion to regulate proliferation of cortical progenitors.
2501628 - Grafting genetically modified cells into the rat brain: characteristics of e. coli beta...
10989188 - Mesenchymal stem cells: biology and potential clinical uses.
7932388 - Studies on the distribution of immune cells in the uteri of prepubertal and cycling gilts.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-6
Journal Detail:
Title:  Brain research     Volume:  -     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-3     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Resonance characteristic and Its Ionic basis of rat mesencephalic trigeminal Neurons.
Next Document:  SUN11602-induced hyperexpression of calbindin D-28k is pivotal for the survival of hippocampal neuro...