| Human umbilical cord blood cells improve cardiac function after myocardial infarction. | |
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MedLine Citation:
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PMID: 15629157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human umbilical cord blood (UCB) contains an abundance of immature stem/progenitor cells and has been clinically used as an alternative to bone marrow transplantation. In addition, cord blood can be obtained non-invasively, in contrast to invasive bone marrow aspiration. We investigated the potential of human UCB CD34(+) cells to improve cardiac function following myocardial infarction. Myocardial infarction was induced in Wistar rats by ligation of the left coronary artery. Either 2x10(5) human UCB CD34(+) cells or equivalent cell-free medium was injected into the injured myocardium of the rats following induction of myocardial infarction. CD34(+) cell transplantation significantly improved ventricular function as compared to the control group. Immunofluorescence staining for human CD34, CD45, and PECAM-1 revealed surviving cells in the myocardium. Our findings suggest that transplanted human cells survived and improved cardiac function following myocardial infarction. These results may show the usefulness of UCB CD34(+) cells for myocardial infarction. |
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Authors:
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Yasutaka Hirata; Masataka Sata; Noboru Motomura; Minoko Takanashi; Yoshihiro Suematsu; Minoru Ono; Shinichi Takamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 327 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-01-04 Completed Date: 2005-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 609-14 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. h-yasu@umin.ac.jp <h-yasu@umin.ac.jp> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD34 / metabolism Cell Survival Fetal Blood / cytology*, metabolism, transplantation* Humans Male Myocardial Infarction / metabolism, pathology*, therapy* Myocardium / metabolism, pathology* Neovascularization, Physiologic Rats Rats, Wistar Stem Cell Transplantation* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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