Document Detail

Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles.
MedLine Citation:
PMID:  17337785     Owner:  NLM     Status:  MEDLINE    
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.
Eva Wieckowski; Theresa L Whiteside
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunologic research     Volume:  36     ISSN:  0257-277X     ISO Abbreviation:  Immunol. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8611087     Medline TA:  Immunol Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Departments of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
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MeSH Terms
Apoptosis / immunology
Cytoplasmic Vesicles / immunology*,  metabolism
Dendritic Cells / immunology*
Exocytosis / immunology
Neoplasms / immunology*
T-Lymphocytes / immunology

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