Document Detail

Human tuberculosis--an ancient disease, as elucidated by ancient microbial biomolecules.
MedLine Citation:
PMID:  19720155     Owner:  NLM     Status:  MEDLINE    
Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term co-existence of host and pathogen. Direct detection and characterisation of ancient microbial DNA and lipid biomarkers confirms palaeopathological diagnoses. Archaeological Mycobacterium tuberculosis resembles extant lineages indicating the timescale for evolutionary changes is considerably longer than originally believed.
Helen D Donoghue
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Publication Detail:
Type:  Historical Article; Journal Article; Review     Date:  2009-08-29
Journal Detail:
Title:  Microbes and infection / Institut Pasteur     Volume:  11     ISSN:  1769-714X     ISO Abbreviation:  Microbes Infect.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883508     Medline TA:  Microbes Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  1156-62     Citation Subset:  IM    
Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London, London W1T 4JF, UK.
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MeSH Terms
DNA, Bacterial / analysis*,  genetics
History, Ancient
Mycobacterium tuberculosis / genetics*
Tuberculosis / epidemiology,  history*,  microbiology
Reg. No./Substance:
0/DNA, Bacterial

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