Document Detail


Human trypanosomiasis in the Ivory Coast: therapy and problems.
MedLine Citation:
PMID:  7902655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human African trypanosomiasis (sleeping sickness) caused by Trypanosoma gambiense is recrudescing alarmingly in the Ivory Coast. Between 1987 and 1992, 980 new cases were registered. In the Bouafle District alone, 214 new cases were diagnosed in 1992, with a prevalence reaching 7% in some villages. This situation is a consequence of the neglect of control activities over the last five years. The problems linked with treatment of sleeping sickness in 626 patients, using three drugs, are described. The side-effects vary in severity according to the drug used. Out of 350 patients treated with melarsoprol (ARSOBAL), 4% developed encephalopathy, 5.7% died during treatment, 2% of encephalopathy. Relapses were noted in 3.7% of patients between 3 and 20 months after treatment. Among 150 patients treated with pentamidine, one case of diabetes mellitus was observed. The patient died of this complication 24 months after treatment. 2% relapses or reinfections were registered after pentamidine treatment. The most frequently encountered side-effects during intravenous plus oral treatment with DFMO were diarrhoea (64.4%) and anemia (35.5%). This drug was just as effective and better tolerated when treatment was limited to 14 days and administered intravenously only.
Authors:
F Doua; F B Yapo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta tropica     Volume:  54     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-12-28     Completed Date:  1993-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Affiliation:
Projet de Recherches Cliniques sur la Trypanosomiase (PRCT), Daloa, Côte d'Ivoire.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cote d'Ivoire / epidemiology
Eflornithine / therapeutic use
Humans
Melarsoprol / administration & dosage,  therapeutic use*
Pentamidine / administration & dosage,  therapeutic use*
Recurrence
Trypanosoma brucei gambiense
Trypanosomiasis, African / drug therapy*,  epidemiology
Chemical
Reg. No./Substance:
100-33-4/Pentamidine; 494-79-1/Melarsoprol; 70052-12-9/Eflornithine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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