| Human tolerance to a single, high dose of D-tagatose. | |
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MedLine Citation:
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PMID: 10341163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The addition of 29 g D-tagatose added as a sweetener to a continental breakfast was tested for the appearance of gastrointestinal side effects in a double-blind randomized cross-over study with 29 g sucrose as a control treatment. The subjects reported the side effects during 72 h following the test meal on a questionnaire grading the symptoms on a five-level scale ranging from "none" to "very strong." Although "rumbling in the stomach," "distention," "nausea," "rumbling in the gut," "flatulence, " and "diarrhea" scored significantly higher with D-tagatose, the sugar otherwise was well tolerated in most of the subjects. Two cases of vomiting after D-tagatose were recorded but in one of the cases its relation to the D-tagatose intake was questionable. Only the "distention" score remained higher with D-tagatose for more than 24 h. Nausea, vomiting, and perceived distension may be due to an osmotic effect in the small intestine of unabsorbed D-tagatose. The increased flatus is caused by D-tagatose being fermented in the large intestine. Diarrhea may be explained by osmotic effects in the colon from nondegraded D-tagatose or nonabsorbed short-chain fatty acids produced by the increased fermentation. |
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Authors:
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B Buemann; S Toubro; A Raben; A Astrup |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory toxicology and pharmacology : RTP Volume: 29 ISSN: 0273-2300 ISO Abbreviation: Regul. Toxicol. Pharmacol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-08-05 Completed Date: 1999-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8214983 Medline TA: Regul Toxicol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S66-70 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Academic Press. |
Affiliation:
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Research Department of Human Nutrition & Centre of Food Research, The Royal Veterinary and Agricultural University, Frederiksberg, 1958, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cross-Over Studies Diarrhea / chemically induced Dietary Sucrose / adverse effects Digestive System / drug effects Double-Blind Method Female Hexoses / adverse effects* Humans Sweetening Agents / adverse effects* Vomiting / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Dietary Sucrose; 0/Hexoses; 0/Sweetening Agents; 17598-81-1/tagatose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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