Document Detail

Human thymocyte responsiveness to stem cell factor: synergy with interleukin-2 for the generation of NK/LAK cytotoxicity.
MedLine Citation:
PMID:  8877418     Owner:  NLM     Status:  MEDLINE    
Human recombinant stem cell factor (SCF) increases the viability and cell size of a subset of thymocytes in vitro, but does not independently induce phenotypic changes on thymocytes indicative of T cell differentiation. The SCF-responsive thymocytes have characteristics of large granular cells, that do not express T, B or NK cell-related antigens, and are primarily found in immature thymocyte subsets. These large granular thymocytes do not display cytotoxic activity. However, SCF acts synergistically with IL-2 in the generation of cytotoxic effector cells from thymocyte precursors. Synergy in cytotoxicity is observed to both NK-sensitive and NK-resistant targets. Studies of the SCF receptors on thymocytes show that receptors are expressed on mature 'bright' CD3+ cells, immature 'dim' CD3+ cells as well as CD3- cells. IL-2 increases the frequency of SCF receptor-positive cells in cultured thymocytes, which may explain its synergy with SCF in the generation of NK/LAK cytotoxicity. These data show that SCF enhances the functional development of thymic NK/LAK cells in vitro.
C H Uittenbogaart; I Schmidc; S Kiertscher; H Shau; D J Anisman; K M Zsebo; L T Clement
Related Documents :
18093538 - Acquisition of a functional t cell receptor during t lymphocyte development is enforced...
18972618 - Lymphocyte subset reconstitution in pediatric liver recipients induced with steroid-fre...
19786978 - Thymocyte expansion and maturation: crosstalk of cd44v6 on thymocytes and pancd44 on st...
10925298 - Deficient in vitro and in vivo phagocytosis of apoptotic t cells by resident murine alv...
16116168 - Costimulation through nkg2d enhances murine cd8+ ctl function: similarities and differe...
24326418 - Involvement of mast cells in adipose tissue fibrosis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunology letters     Volume:  52     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1997-02-06     Completed Date:  1997-02-06     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  45-52     Citation Subset:  IM    
Department of Pediatrics, UCLA School of Medicine, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antigens, CD / analysis
Cell Differentiation
Cells, Cultured
Cytotoxicity, Immunologic*
Drug Synergism
Hematopoietic Stem Cells / drug effects*
Interleukin-2 / pharmacology*
Killer Cells, Lymphokine-Activated
Killer Cells, Natural / immunology*
Proto-Oncogene Proteins c-kit / analysis
Stem Cell Factor / pharmacology*
Thymus Gland / cytology*,  drug effects,  immunology
Grant Support
Reg. No./Substance:
0/Antigens, CD; 0/Interleukin-2; 0/Stem Cell Factor; EC Proteins c-kit

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  HIV-1 epitopes exposed by hybrid hepatitis B core particles affect proliferation of peripheral blood...
Next Document:  Soybean agglutinin binds a 160-kDa rat macrophage membrane glycoprotein and enhances cell differenti...