Document Detail

Human thrombin for the treatment of gastric and ectopic varices.
MedLine Citation:
PMID:  23139607     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the efficacy of human thrombin in the treatment of bleeding gastric and ectopic varices.
METHODS: Retrospective observational study in a Tertiary Referral Centre. Between January 1999-October 2005, we identified 37 patients who were endoscopically treated with human thrombin injection therapy for bleeding gastric and ectopic varices. Patient details including age, gender and aetiology of liver disease/segmental portal hypertension were documented. The thrombin was obtained from the Scottish National Blood Transfusion Service and prepared to give a solution of 250 IU/mL which was injected via a standard injection needle. All patient case notes were reviewed and the total dose of thrombin given along with the number of endoscopy sessions was recorded. Initial haemostasis rates, rebleeding rates and mortality were catalogued along with the incidence of any immediate complications which could be attributable to the thrombin therapy. The duration of follow up was also listed. The study was conducted according to the United Kingdom research ethics guidelines.
RESULTS: Thirty-seven patients were included. 33 patients (89%) had thrombin (250 U/mL) for gastric varices, 2 (5.4%) for duodenal varices, 1 for rectal varices and 1 for gastric and rectal varices. (1) Gastric varices, an average of 15.2 mL of thrombin was used per patient. Re-bleeding occurred in 4 patients (10.8%), managed in 2 by a transjugular intrahepatic portosystemic shunt (TIPSS) (one unsuccessfully who died) and in other 2 by a distal splenorenal shunt; (2) Duodenal varices (or type 2 isolated gastric varices), an average of 12.5 mL was used per patient over 2-3 endoscopy sessions. Re-bleeding occurred in one patient, which was treated by TIPSS; and (3) Rectal varices, an average of 18.3 mL was used per patient over 3 endoscopy sessions. No re-bleeding occurred in this group.
CONCLUSION: Human thrombin is a safe, easy to use and effective therapeutic option to control haemorrhage from gastric and ectopic varices.
Norma C McAvoy; John N Plevris; Peter C Hayes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-11-12     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5912-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Esophageal and Gastric Varices / drug therapy*,  mortality
Gastrointestinal Hemorrhage / drug therapy*,  mortality
Hemostasis, Endoscopic / adverse effects,  methods*,  mortality
Hemostatics / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Retrospective Studies
Tertiary Care Centers
Thrombin / administration & dosage,  adverse effects,  therapeutic use*
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Hemostatics; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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