Document Detail

Human temporomandibular joint morphogenesis.
MedLine Citation:
PMID:  18333411     Owner:  NLM     Status:  MEDLINE    
Temporomandibular joint morphogenesis was studied. Ranging in age of fetuses examined was from 6 to14 weeks' gestation. Our results showed the condyle so first element that appear between 6 degrees and 8 degrees week (condylar blastema). After a week appear temporal elements. Disk appear at the same time of glenoid blastema and it reaches an advanced differentation before of the condyle and temporal element, so these don't effect machanical compression on mesenchyma where we find the disk. So we think that the disk result of genetic expression and it isn't the result of mechanical compression. The inferior joint cavity appear to 12 week. The superior joint cavity appear to 13-14 week. In conclusion, the appearance of the condyle is the first event during TMJ morphogenesis, with its initial bud, in form of a mesenchymal thickening, becoming detectable between the sixth and eight week of development, when all the large joints of the limbs are already well defined.
Francesco Carini; Giuseppe Alessandro Scardina; Carola Caradonna; Pietro Messina; Vincenzo Valenza
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia     Volume:  112     ISSN:  1122-6714     ISO Abbreviation:  Ital J Anat Embryol     Publication Date:    2007 Oct-Dec
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-04-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612303     Medline TA:  Ital J Anat Embryol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  267-75     Citation Subset:  IM    
Department of Experimental Medicine, Section of Human Anatomy, University of Palermo, Italy.
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MeSH Terms
Body Patterning / physiology*
Mandibular Condyle / embryology,  physiology
Mesoderm / cytology,  physiology
Organogenesis / physiology*
Synovial Membrane / embryology,  physiology
Temporomandibular Joint / embryology*,  physiology
Temporomandibular Joint Disk / embryology,  physiology

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