| Human telomerase caught in the act. | |
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MedLine Citation:
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PMID: 19665967 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on prior work, it was expected that telomerase would preferentially elongate the shortest telomeres in a cell, extending the telomeric G-rich strand through a process that is coupled to the synthesis of the complementary strand. Contrary to this view, Zhao et al. (2009) now show that telomerase in human cancer cells extends most telomeres during every S phase and that complementary strand synthesis does not immediately follow telomerase action. |
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Authors:
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Peng Wu; Titia de Lange |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cell Volume: 138 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-11 Completed Date: 2009-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 432-4 Citation Subset: IM |
Affiliation:
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The Rockefeller University, New York, NY 10065, USA. pwu01@mail.rockefeller.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line, Tumor Humans S Phase Telomerase / metabolism* Telomere / metabolism |
| Chemical | |
Reg. No./Substance:
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EC 2.7.7.49/Telomerase |
| Comments/Corrections | |
Comment On:
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Cell. 2009 Aug 7;138(3):463-75
[PMID:
19665970
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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