Document Detail

Human stratum corneum penetration by nickel. In vivo study of depth distribution after occlusive application of the metal as powder.
MedLine Citation:
PMID:  11802474     Owner:  NLM     Status:  MEDLINE    
Sequential tape stripping was implemented on three healthy volunteers to examine the surface distribution of nickel through human stratum corneum in vivo following occlusive application of the metal as powder on the volar forearm. Exposure sites were stripped 20 times at intervals from 5 min to 96 h post-dosing and the strips analyzed for metal content by Inductively Coupled Plasma-Mass Spectroscopy with a detection limit for nickel of 0.5 ppb. The gradients of nickel distribution profiles increased proportionally with occlusion time, but after the 10th strip to the 20th strip continued at constant levels. Total nickel removed with 20 stratum corneum strips to the level of the glistening layer after maximum occlusion of 96 h was 41.6 micrograms/cm2 (+/- 12.2; average n = 3). In order to normalize the nickel depth distribution profiles, stratum corneum removed by stripping of untreated skin after occlusion was determined by weighing. Following application of nickel dust over 24 h, analysis of the 20th strip still indicated nickel present at 1.42 micrograms/cm2 (+/- 0.68; average n = 3). These data indicate that, in contact with skin, nickel metal is oxidized to form soluble, stratum corneum-diffusible compounds which may penetrate the intact stratum corneum, presumably by the intercellular route, and have the potential to elicit allergic reactions.
J J Hostýnek; F Dreher; A Pelosi; A Anigbogu; H I Maibach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica. Supplementum     Volume:  -     ISSN:  0365-8341     ISO Abbreviation:  Acta Derm Venereol Suppl (Stockh)     Publication Date:  2001  
Date Detail:
Created Date:  2002-01-22     Completed Date:  2002-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370311     Medline TA:  Acta Derm Venereol Suppl (Stockh)     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  5-10     Citation Subset:  IM    
Euromerican Technology Resources, Inc., Lafayette, USA.
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MeSH Terms
Dermatitis, Allergic Contact / etiology*
Middle Aged
Nickel / adverse effects,  metabolism*
Reagent Strips
Regression Analysis
Skin Absorption*
Reg. No./Substance:
0/Powders; 0/Reagent Strips; 7440-02-0/Nickel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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