| Human squamous cell carcinoma. Establishment and characterization of new permanent cell lines. | |
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MedLine Citation:
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PMID: 7295166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Squamous cell carcinoma is the most common of human cancers, and yet because it is poorly represented by cultured cell lines, little is known about the characteristic cell biology and the cell-surface antigenic phenotypes of such tumors. To develop a continuously available source of squamous cell carcinoma for repeated and reproducible serologic analysis and for better understanding of its biologic characteristics, tissue culture methods and nude mice were used to establish new cell lines of squamous carcinoma. Special media, serum supplements from several sources, and methods of handling fresh tissue specimens were all examined as a means of improving the survival of tumor cell lines. Several new cell lines were established. Features characteristic of a squamous cell origin, eg, microvilli, desmosomes, tonofilaments, and the squamous cell differentiation antigen (pemphigus antigen), were found. The clinical course of disease in individual donor patients has been examined. |
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Authors:
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C J Krause; T E Carey; R W Ott; C Hurbis; K D McClatchey; J A Regezi |
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Publication Detail:
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Type: Case Reports; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of otolaryngology (Chicago, Ill. : 1960) Volume: 107 ISSN: 0003-9977 ISO Abbreviation: Arch Otolaryngol Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1981-12-21 Completed Date: 1981-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376526 Medline TA: Arch Otolaryngol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 703-10 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Animals Antigens, Neoplasm / immunology Carcinoma, Squamous Cell / immunology, pathology* Cell Line* Humans Male Mice Mice, Nude Mouth Neoplasms / immunology, pathology* Neoplasm Transplantation Neoplasms, Experimental |
| Grant Support | |
ID/Acronym/Agency:
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CA-00621/CA/NCI NIH HHS; CA-28564/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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