Document Detail

Human sperm chromosome analysis--study on human sperm chromosome mutagenesis induced by carbon disulfide.
MedLine Citation:
PMID:  8721625     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the effect CS2 of on human sperm chromosomal aberration. The human sperm/hamster egg fusion technique was used to analyze 203 human sperm chromosome complement from 9 healthy volunteers. The incidence of numerical aberration was 1.0% and that of structural chromosome aberration was 5.9% and total abnormalities was 6.9%. Structural aberrations consisted of breaks, deletions, centric rings, fragments, and chromatid exchange. The results from high concentration group (10 mumol.L-1 CS2) showed that the incidence of chromosomal aberration rate was significantly higher than that of the control group. The results indicate that high concentration of CS2 might directly cause mutagenesis of the germ cell.
J Y Le; X M Fu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biomedical and environmental sciences : BES     Volume:  9     ISSN:  0895-3988     ISO Abbreviation:  Biomed. Environ. Sci.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-19     Completed Date:  1996-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8909524     Medline TA:  Biomed Environ Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-40     Citation Subset:  IM    
Zhejiang Academy of Medical Sciences, Hangzhou, China.
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MeSH Terms
Carbon Disulfide / toxicity*
Chromosome Aberrations*
Mutagenicity Tests
Spermatozoa / drug effects*,  ultrastructure
Reg. No./Substance:
75-15-0/Carbon Disulfide

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