| Human serum albumin levels and cardiovascular risk factors in elderly Japanese-American men: the Honolulu Heart Program. | |
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MedLine Citation:
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PMID: 17621861 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study is to investigate the relationship between lowlevels of human serum albumin (HSA) and the incidence of coronary heart disease (CHD) in a cohort of elderly Japanese-American men. Using data from the Honolulu Heart Program's fourth examination (1991-1993), HSA levels of 998 Japanese American men aged 71-93 years was compared with plasma levels of fibrinogen, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, diastolic BP, BMI, and fasting blood glucose. HSA was significantly negatively associated with age and fibrinogen, and significantly positively associated with total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, diastolic BP, BMI and fasting blood glucose. After adjusting for age, tertiles of HSA were significantly positively associated with total cholesterol, HDL cholesterol and triglycerides, and significantly negatively associated with fibrinogen. Using multivariate stepwise regression, significant correlations were seen between HSA and fibrinogen, cholesterol, age, HDL cholesterol and triglycerides, and a borderline correlation was seen with systolic blood pressure. However, the model R-square for all variables was only 0.10. In conclusion, HSA levels are significantly associated with several traditional cardiovascular risk factors, particularly serum lipid levels. |
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Authors:
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Chung-Eun Ha; Kamal H Masaki; Helen Petrovitch; Randi Chen; Lenore Launer; Nadhipuram V Bhagavan; Alan T Remaley; J David Curb |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Hawaii medical journal Volume: 66 ISSN: 0017-8594 ISO Abbreviation: Hawaii Med J Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-11 Completed Date: 2007-08-23 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 2984209R Medline TA: Hawaii Med J Country: United States |
Other Details:
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Languages: eng Pagination: 148, 150-2 Citation Subset: IM |
Affiliation:
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Department of Native Hawaiian Health, John A Burns School of Medicine, University of Hawai'i, Honolulu 96813, USA. chungeun@hawaii.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cholesterol / blood* Cholesterol, HDL / blood Cholesterol, LDL / analysis Coronary Disease / blood*, epidemiology* Fibrinogen / analysis Hawaii / epidemiology Humans Male Risk Factors Serum Albumin / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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N01-HC-05102/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Serum Albumin; 57-88-5/Cholesterol; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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