Document Detail


Human seizures self-terminate across spatial scales via a critical transition.
MedLine Citation:
PMID:  23213262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Why seizures spontaneously terminate remains an unanswered fundamental question of epileptology. Here we present evidence that seizures self-terminate via a discontinuous critical transition or bifurcation. We show that human brain electrical activity at various spatial scales exhibits common dynamical signatures of an impending critical transition--slowing, increased correlation, and flickering--in the approach to seizure termination. In contrast, prolonged seizures (status epilepticus) repeatedly approach, but do not cross, the critical transition. To support these results, we implement a computational model that demonstrates that alternative stable attractors, representing the ictal and postictal states, emulate the observed dynamics. These results suggest that self-terminating seizures end through a common dynamical mechanism. This description constrains the specific biophysical mechanisms underlying seizure termination, suggests a dynamical understanding of status epilepticus, and demonstrates an accessible system for studying critical transitions in nature.
Authors:
Mark A Kramer; Wilson Truccolo; Uri T Eden; Kyle Q Lepage; Leigh R Hochberg; Emad N Eskandar; Joseph R Madsen; Jong W Lee; Atul Maheshwari; Eric Halgren; Catherine J Chu; Sydney S Cash
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-04
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-19     Completed Date:  2013-02-28     Revised Date:  2014-06-27    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21116-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biophysics / methods
Brain / physiopathology*
Brain Mapping / methods
Computer Simulation
Electrocardiography / methods
Electrodes
Electroencephalography / methods
Female
Humans
Male
Middle Aged
Models, Biological
Seizures / physiopathology*
Status Epilepticus / physiopathology*
Grant Support
ID/Acronym/Agency:
K01 NS057389/NS/NINDS NIH HHS; K01 NS057389/NS/NINDS NIH HHS; K12 NS066225/NS/NINDS NIH HHS; R01 NS072023/NS/NINDS NIH HHS; R01 NS079533/NS/NINDS NIH HHS; R01NS072023/NS/NINDS NIH HHS; R01NS079533/NS/NINDS NIH HHS; SNS062092//PHS HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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