Document Detail

Human saphenous vein coronary artery bypass graft morphology, geometry and hemodynamics.
MedLine Citation:
PMID:  15868720     Owner:  NLM     Status:  MEDLINE    
Coronary artery bypass graft (CABG) failure has been linked to graft hemodynamics, in particular wall shear stress. This study characterizes the morphology, geometry and wall shear stress patterns in human CABGs. The intimal thickness (IT) in 49 human saphenous vein CABGs was measured by digital light microscopy. The geometry of six saphenous vein CABGs was replicated by post-mortem infusion of Batson's #17 anatomical corrosion casting compound. Graft hemodynamics were evaluated in two flow models, fabricated from the casts, under steady (Re = 110) and pulsatile flow (Re = 110, alpha = 2) conditions. Saphenous vein CABGs in situ for more than 2 months had, on average, the greatest IT on the hood and suture sites of the distal anastomosis. Floor thickening was highly variable and significantly less than IT at the hood, suture site and graft body. All casts showed an indentation along the floor and 5/6 casts displayed a sharp local curvature on the hood. In both flow models, a large increase in wall shear rate occurred on the hood, just proximal to the toe. The local geometry of the hood created this large spatial gradient in wall shear stress which is a likely factor in hood intimal hyperplasia.
Richard L Leask; Jagdish Butany; K Wayne Johnston; C Ross Ethier; Matadial Ojha
Publication Detail:
Type:  Evaluation Studies; In Vitro; Journal Article    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  33     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-04     Completed Date:  2005-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  301-9     Citation Subset:  IM    
Department of Chemical Engineering, McGill University, Montreal, Quebec.
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MeSH Terms
Blood Flow Velocity
Blood Pressure
Coronary Artery Bypass / methods*
Coronary Vessels / pathology,  physiopathology*,  surgery*
Models, Anatomic*
Models, Cardiovascular*
Saphenous Vein / pathology,  physiopathology*,  transplantation*
Shear Strength

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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