Document Detail

Human rotavirus strains bearing VP4 gene P[6] allele recovered from asymptomatic or symptomatic infections share similar, if not identical, VP4 neutralization specificities.
MedLine Citation:
PMID:  14599785     Owner:  NLM     Status:  MEDLINE    
A rotavirus VP4 gene P[6] allele has been documented in a number of countries to be characteristically associated with an endemic predominantly asymptomatic infection in neonates in maternity hospital nurseries. The mechanisms underlying the endemicity and asymptomatic nature of such neonatal infections remain unknown. Rotavirus strains sharing this same P genotype, however, have more recently been recovered from an increasing number of symptomatic diarrheal episodes in infants and young children in various parts of the world. Previously, we have shown that an asymptomatic P[6] rotavirus neonatal infection is not associated with a unique VP7 (G) serotype but may occur in conjunction with various G types. Although amino acid sequence comparisons of the VP4 gene between selected "asymptomatic" and "symptomatic" P[6] rotavirus strains have been reported and yielded information concerning their VP4 genotypes, serotypic comparisons of the outer capsid spike protein VP4 of such viruses have not been studied systematically by two-way cross-neutralizations. We determined the VP4 neutralization specificities of four asymptomatic and four symptomatic P[6] strains: two each of asymptomatic and symptomatic strains by two-way tests, and two each of additional asymptomatic and symptomatic strains by one-way tests. Both asymptomatic and symptomatic P[6] strains were shown to bear similar, if not identical, VP4 neutralization specificities. Thus, P[6] rotavirus strains causing asymptomatic or symptomatic infections did not appear to belong to unique P (VP4) serotypes. In addition, a close VP4 serotypic relationship between human P[6] rotavirus strains and the porcine P[6] rotavirus Gottfried strain was confirmed.
Yasutaka Hoshino; Ronald W Jones; Jerri Ross; Norma Santos; Albert Z Kapikian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virology     Volume:  316     ISSN:  0042-6822     ISO Abbreviation:  Virology     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2003-12-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0110674     Medline TA:  Virology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8026, USA.
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MeSH Terms
Antibodies, Viral / blood,  immunology
Antigens, Viral*
Capsid Proteins / genetics*,  immunology
Child, Preschool
Guinea Pigs
Infant, Newborn
Neutralization Tests
Reassortant Viruses / genetics,  immunology
Recombination, Genetic
Rotavirus / classification,  genetics,  immunology*,  isolation & purification
Rotavirus Infections / physiopathology*,  virology
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Capsid Proteins; 0/VP4 protein, Rotavirus; 0/VP7 protein, Rotavirus

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