Document Detail


Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro.
MedLine Citation:
PMID:  2985827     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the characteristics of picornavirus infection of cells in tissue culture is a specific inhibition of utilization of host cell mRNA for protein synthesis. In this study we show that human rhinovirus 14 is similar to poliovirus in that the inhibition of host cell translation that occurs during infection correlates with the proteolytic cleavage of an Mr 220,000 subunit of the cap-binding protein complex.
Authors:
D Etchison; S Fout
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of virology     Volume:  54     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  1985 May 
Date Detail:
Created Date:  1985-05-29     Completed Date:  1985-05-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  634-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Carrier Proteins / metabolism*
Globins / biosynthesis*
Hela Cells / microbiology
Humans
Molecular Weight
Peptide Initiation Factors / isolation & purification
Protein Biosynthesis*
RNA Cap-Binding Proteins
Rhinovirus / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
AI-19921/AI/NIAID NIH HHS; GM-22135/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Peptide Initiation Factors; 0/RNA Cap-Binding Proteins; 9004-22-2/Globins
Comments/Corrections

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