| Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro. | |
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MedLine Citation:
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PMID: 2985827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the characteristics of picornavirus infection of cells in tissue culture is a specific inhibition of utilization of host cell mRNA for protein synthesis. In this study we show that human rhinovirus 14 is similar to poliovirus in that the inhibition of host cell translation that occurs during infection correlates with the proteolytic cleavage of an Mr 220,000 subunit of the cap-binding protein complex. |
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Authors:
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D Etchison; S Fout |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of virology Volume: 54 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-05-29 Completed Date: 1985-05-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 634-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carrier Proteins
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metabolism* Globins / biosynthesis* Hela Cells / microbiology Humans Molecular Weight Peptide Initiation Factors / isolation & purification Protein Biosynthesis* RNA Cap-Binding Proteins Rhinovirus / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AI-19921/AI/NIAID NIH HHS; GM-22135/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Peptide Initiation Factors; 0/RNA Cap-Binding Proteins; 9004-22-2/Globins |
| Comments/Corrections | |
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