| Human reproductive failure II: immunogenetic and interacting factors. | |
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MedLine Citation:
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PMID: 11284659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies in humans suggest that reproductive failure may be influenced by immunological factors or by genes encoding immunological factors and regulatory mechanisms controlling immunological expression. Using molecular methods, immunological factors can be clearly studied in an immunogenetic context. One example, the major histocompatibility complex (MHC), known as the human leukocyte antigens (HLA) in humans and MHC in other mammals, affects many different stages of reproduction. Studies in some outbred, and in closely related, human populations indicate that HLA, or HLA-linked, genes and HLA regulatory factors affect gamete development, embryo cleavage, blastocyst and trophoblast formation, implantation, fetal development and survival. Studies in non-human mammals indicate that MHC, or MHC-linked, genes such as the grc complex, Ped/Qa-2, t haplotypes and MHC regulatory factors, have similar reproductive effects. Human reproductive failure may also be a consequence of disruption of interacting factors, including interactions between HLA antigens, cytokines and natural killer (NK) cells. In this review, we highlight the importance of immunogenetic and interacting factors in human reproductive failure. We argue that studies in closely related human populations and animal models may contribute to a better understanding of the ways in which immunogenetic and interacting factors are involved in human reproduction. |
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Authors:
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S R Choudhury; L A Knapp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Human reproduction update Volume: 7 ISSN: 1355-4786 ISO Abbreviation: Hum. Reprod. Update Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-04-03 Completed Date: 2001-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9507614 Medline TA: Hum Reprod Update Country: England |
Other Details:
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Languages: eng Pagination: 135-60 Citation Subset: IM |
Affiliation:
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Department of Biological Anthropology, University of Cambridge, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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genetics,
immunology* Cytokines / genetics, immunology Embryonic and Fetal Development / genetics, immunology* Female Fetal Death / genetics, immunology* Gene Expression Regulation, Developmental / immunology HLA Antigens / genetics, immunology* Humans Killer Cells, Natural / immunology Male Pregnancy Reproduction / genetics, immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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