Document Detail


Human regulatory gene for inducible tyrosine aminotransferase in rat-human hybrids.
MedLine Citation:
PMID:  4146214     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inducibility of tyrosine aminotransferase (EC 2.6.1.5) by corticosteroid hormones in rat-human hybrid clones was studied. The presence of human X chromosome activity in the cells was always associated with the suppression of tyrosine aminotransferase inducibility in all the clones examined. Negative correlation between the human X chromosome and inducibility of the enzyme was clearly established. Corticosteroid receptor was present to the same extent in hybrid cell clones that either contained or lost the human X chromosome. The human repressor for inducible tyrosine aminotransferase has a linkage relationship with glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and hypoxanthine-guanine-phosphoribosyltransferase (EC 2.4.2.8) and, therefore, can be assigned to the X chromosome.
Authors:
C M Croce; G Litwack; H Koprowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  70     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1973 Apr 
Date Detail:
Created Date:  1973-09-12     Completed Date:  1973-09-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1268-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma, Hepatocellular
Cell Line
Clone Cells
Dexamethasone / pharmacology
Embryo, Mammalian
Enzyme Induction / drug effects
Enzyme Repression
Female
Genes, Regulator*
Glucosephosphate Dehydrogenase
Humans
Hybrid Cells / enzymology*
Karyotyping
Linkage (Genetics)
Liver Neoplasms
Lung
Pentosyltransferases
Rats
Sex Chromosomes
Tyrosine Transaminase / biosynthesis*
Chemical
Reg. No./Substance:
50-02-2/Dexamethasone; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.4.2.-/Pentosyltransferases; EC 2.6.1.5/Tyrosine Transaminase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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