Document Detail


Human recombinant interleukin-1 alpha is proinflammatory in normal human skin.
MedLine Citation:
PMID:  3272749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The proinflammatory effects of recombinant human interleukin-1 alpha (HRIL-1 alpha) have been determined in the skin of normal human volunteers. Intradermal injection of 10, 50 and 100 U HRIL-1 alpha produced dose-related erythema which first appeared at 2 h, was maximal around 24 h, persisted for up to 48 h, and was associated with oedema. Histological examination revealed dermal mononuclear cell infiltrates, which were accompanied by neutrophils at 4 and 8 h. Injection of heat-treated HRIL-1 alpha (100 U) produced no erythema or oedema. These results demonstrate the potent proinflammatory properties of HRIL-1 alpha in human skin.
Authors:
P M Dowd; R D Camp; M W Greaves
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Skin pharmacology : the official journal of the Skin Pharmacology Society     Volume:  1     ISSN:  1011-0283     ISO Abbreviation:  Skin Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1990-04-16     Completed Date:  1990-04-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8810069     Medline TA:  Skin Pharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  30-7     Citation Subset:  IM    
Affiliation:
Institute of Dermatology, United Medical School, St. Thomas' Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Sedimentation
C-Reactive Protein / metabolism
Dermatitis / etiology,  pathology*
Dose-Response Relationship, Drug
Female
Humans
Injections, Intradermal
Interleukin-1 / administration & dosage,  pharmacology*
Leukocyte Count
Male
Neutrophils / drug effects
Recombinant Proteins / administration & dosage,  pharmacology
Skin / pathology
Chemical
Reg. No./Substance:
0/Interleukin-1; 0/Recombinant Proteins; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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