Document Detail

Human and recombinant erythropoietin stimulate erythropoiesis in the goldfish Carassius auratus.
MedLine Citation:
PMID:  9491316     Owner:  NLM     Status:  MEDLINE    
Erythropoietin (EPO) stimulates differentiation of erythrocytes and biosynthesis of haemoglobin in mammals. It has not been confirmed that EPO is effective in other vertebrates, so we attempted to verify the effectiveness of human-urinary and recombinant EPO on erythropoiesis of the goldfish Carassius auratus. The results indicate that both types of EPO produce an increase in haemoglobin, erythrocytes and erythroblasts number in peripheral blood of the goldfish; moreover, they stimulate erythropoiesis in lymphomyeloid tissue of kidney which, in normal conditions we find to be prevalently myelopoietic.
R Taglialatela; F Della Corte
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of histochemistry : EJH     Volume:  41     ISSN:  1121-760X     ISO Abbreviation:  Eur J Histochem     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-14     Completed Date:  1998-04-14     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  9207930     Medline TA:  Eur J Histochem     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Erythroblasts / drug effects
Erythrocyte Count / drug effects
Erythropoiesis / drug effects*
Erythropoietin / pharmacology*
Erythropoietin, Recombinant / pharmacology*
Goldfish / blood*
Hemoglobins / drug effects,  metabolism
Reg. No./Substance:
0/Erythropoietin, Recombinant; 0/Hemoglobins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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