Document Detail


Human pulmonary vascular responses to hypoxia and hypercapnia.
MedLine Citation:
PMID:  15322849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of alveolar gas composition to influence pulmonary vascular tone has been appreciated for over 50 years. In particular, it has been proposed that both O2 and CO2 could play a role in the matching of perfusion to ventilation within the lung, improving the overall efficiency of gas exchange. A wide variety of experimental approaches has been used to investigate pulmonary vascular effects of the respiratory gases in a range of mammalian species. In this article, we review experiments performed in healthy humans, identify particular difficulties in the interpretation of such experiments, and discuss possible approaches to future study.
Authors:
K L Dorrington; N P Talbot
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  449     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2005-04-13     Completed Date:  2005-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-15     Citation Subset:  IM    
Affiliation:
University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom. keith.dorrington@physiol.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Altitude
Animals
Anoxia*
Blood Vessels / cytology,  metabolism*
Humans
Hypercapnia*
Lung / blood supply*,  metabolism
Pulmonary Circulation / physiology*
Vascular Resistance
Vasoconstriction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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