| Human pulmonary vascular responses to hypoxia and hypercapnia. | |
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MedLine Citation:
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PMID: 15322849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of alveolar gas composition to influence pulmonary vascular tone has been appreciated for over 50 years. In particular, it has been proposed that both O2 and CO2 could play a role in the matching of perfusion to ventilation within the lung, improving the overall efficiency of gas exchange. A wide variety of experimental approaches has been used to investigate pulmonary vascular effects of the respiratory gases in a range of mammalian species. In this article, we review experiments performed in healthy humans, identify particular difficulties in the interpretation of such experiments, and discuss possible approaches to future study. |
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Authors:
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K L Dorrington; N P Talbot |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 449 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2005-04-13 Completed Date: 2005-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 1-15 Citation Subset: IM |
Affiliation:
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University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom. keith.dorrington@physiol.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Altitude Animals Anoxia* Blood Vessels / cytology, metabolism* Humans Hypercapnia* Lung / blood supply*, metabolism Pulmonary Circulation / physiology* Vascular Resistance Vasoconstriction |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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