Document Detail

Human prolactin secreting adenoma cells maintained on extracellular matrix.
MedLine Citation:
PMID:  7193118     Owner:  NLM     Status:  MEDLINE    
In vitro maintenance of human prolactin secreting adenoma cells on a extracellular matrix (ECM) produced by bovine corneal endothelial cells is associated with the adoption of morphological properties that are not expressed when the cells are seeded on plastic. Cells seeded on ECM were firmly attached and highly flattened, whereas cells seeded on plastic formed aggregates which were loosely attached or floated in the medium. Moreover, prolactin production from cells on ECM is frequently stable for several weeks. Both tumor cells and normal cells are more likely to resemble their in vivo counterparts when maintained on extracellular matrix than on plastic, and therefore, cells cultured on ECM may provide a better system for oncogenic and endocrine studies.
C L Bethea; R I Weiner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  108     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  AIM; IM    
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MeSH Terms
Adenoma / metabolism*
Cells, Cultured
Cornea / cytology
Neoplasms, Experimental / metabolism
Pituitary Neoplasms / metabolism*
Prolactin / secretion*
Grant Support
Reg. No./Substance:

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