Document Detail

Human progenitor cells derived from cardiac adipose tissue ameliorate myocardial infarction in rodents.
MedLine Citation:
PMID:  20713059     Owner:  NLM     Status:  MEDLINE    
Myocardial infarction caused by vascular occlusion results in the formation of nonfunctional fibrous tissue. Cumulative evidence indicates that cell therapy modestly improves cardiac function; thus, novel cell sources with the potential to repair injured tissue are actively sought. Here, we identify and characterize a cell population of cardiac adipose tissue-derived progenitor cells (ATDPCs) from biopsies of human adult cardiac adipose tissue. Cardiac ATDPCs express a mesenchymal stem cell-like marker profile (strongly positive for CD105, CD44, CD166, CD29 and CD90) and have immunosuppressive capacity. Moreover, cardiac ATDPCs have an inherent cardiac-like phenotype and were able to express de novo myocardial and endothelial markers in vitro but not to differentiate into adipocytes. In addition, when cardiac ATDPCs were transplanted into injured myocardium in mouse and rat models of myocardial infarction, the engrafted cells expressed cardiac (troponin I, sarcomeric α-actinin) and endothelial (CD31) markers, vascularization increased, and infarct size was reduced in mice and rats. Moreover, significant differences between control and cell-treated groups were found in fractional shortening and ejection fraction, and the anterior wall remained significantly thicker 30days after cardiac delivery of ATDPCs. Finally, cardiac ATDPCs secreted proangiogenic factors under in vitro hypoxic conditions, suggesting a paracrine effect to promote local vascularization. Our results indicate that the population of progenitor cells isolated from human cardiac adipose tissue (cardiac ATDPCs) may be valid candidates for future use in cell therapy to regenerate injured myocardium.
Antoni Bayes-Genis; Carolina Soler-Botija; Jordi Farré; Pilar Sepúlveda; Angel Raya; Santiago Roura; Cristina Prat-Vidal; Carolina Gálvez-Montón; José Anastasio Montero; Dirk Büscher; Juan Carlos Izpisúa Belmonte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-14
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  49     ISSN:  1095-8584     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-01-18     Revised Date:  2011-12-15    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  771-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Laboratory of Cell Physiology, Department of Cardiology, Hospital de la Santa Creu i Sant Pau, ICCC, Barcelona, Spain.
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MeSH Terms
Adipose Tissue / cytology*
Angiogenesis Inducing Agents / metabolism
Capillaries / pathology
Cell Differentiation
Cell Lineage
Cell Separation
Cells, Cultured
Coculture Techniques
Endothelial Cells / cytology,  metabolism
Heart Function Tests
Myocardial Infarction / pathology,  therapy*,  ultrasonography
Myocardium / cytology*
Neovascularization, Physiologic
Stem Cell Transplantation*
Stem Cells / cytology*
Reg. No./Substance:
0/Angiogenesis Inducing Agents

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