| Human primary gastric dendritic cells induce a Th1 response to H. pylori. | |
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MedLine Citation:
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PMID: 20237463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adaptive CD4 T-cell responses are important in the pathogenesis of chronic Helicobacter pylori gastritis. However, the gastric antigen-presenting cells that induce these responses have not yet been identified. Here we show that dendritic cells (DCs) are present in the gastric mucosa of healthy subjects and are more prevalent and more activated in the gastric mucosa of H. pylori-infected subjects. H. pylori induced gastric DCs isolated from noninfected subjects to express increased levels of CD11c, CD86 and CD83, and to secrete proinflammatory cytokines, particularly interleukin (IL)-6 and IL-8. Importantly, gastric DCs pulsed with live H. pylori, but not control DCs, mediated T-cell secretion of interferon-gamma. The ability of H. pylori to induce gastric DC maturation and stimulate gastric DC activation of Th1 cells implicates gastric DCs as initiators of the immune response to H. pylori. |
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Authors:
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D Bimczok; R H Clements; K B Waites; L Novak; D E Eckhoff; P J Mannon; P D Smith; L E Smythies |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-03-17 |
Journal Detail:
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Title: Mucosal immunology Volume: 3 ISSN: 1935-3456 ISO Abbreviation: Mucosal Immunol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-07-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101299742 Medline TA: Mucosal Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 260-9 Citation Subset: IM |
Affiliation:
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Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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immunology,
metabolism Cytokines / immunology, metabolism Dendritic Cells / immunology*, metabolism Female Gastric Mucosa / immunology*, metabolism Helicobacter Infections / immunology*, metabolism Helicobacter pylori / immunology*, metabolism Humans Lymphocyte Activation / immunology* Male Th1 Cells / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AI-78217/AI/NIAID NIH HHS; AI-83539/AI/NIAID NIH HHS; DK-084063/DK/NIDDK NIH HHS; DK-47322/DK/NIDDK NIH HHS; DK-54495/DK/NIDDK NIH HHS; DK-64400/DK/NIDDK NIH HHS; RR-20136/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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