| Human pregnancy serum inhibits interleukin-2 production. | |
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MedLine Citation:
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PMID: 6239719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell-mediated immunity may be depressed during pregnancy. We used the two way mixed lymphocyte reaction as an in vitro model of cell mediated immunity and studied the effect of pregnancy sera on this system by the amount of tritiated thymidine taken up by activated lymphocytes. We found that: (1) pregnancy sera contain a factor inhibiting the mixed lymphocyte reaction; (2) the inhibition of the mixed lymphocyte reaction induced by sera could be reversed by the addition of the supernatant from allogeneic mixed lymphocyte reaction; (3) pure interleukin-1 could not reverse the inhibitory effect and (4) recombinant interleukin-2 (IL-2) completely reversed the inhibitory effect of pregnancy sera on the mixed lymphocyte reaction. We conclude that a factor (or factors) present in serum from pregnant women is capable of inhibiting the generation of IL-2 during lymphocyte activation. |
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Authors:
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N S Nicholas; G S Panayi; A M Nouri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 58 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-14 Completed Date: 1985-02-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 587-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood* Female Humans Immunity, Cellular Interleukin-1 / immunology Interleukin-2 / biosynthesis* Lymphocyte Activation Lymphocyte Culture Test, Mixed Male Pregnancy* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Interleukin-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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