Document Detail


Human postprandial gastric emptying of 1-3-millimeter spheres.
MedLine Citation:
PMID:  3360258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microspheres of pancreatin should empty from the stomachs of patients with pancreatic insufficiency as fast as food. The present study was undertaken in 26 healthy subjects to identify the size of spheres that would empty from the stomach with food and to determine whether different meals alter this size. Spheres of predefined sizes were labeled with 113mIn or 99mTc. Using a gamma-camera, we studied the concurrent gastric emptying of spheres labeled with 113mIn and of chicken liver labeled with 99mTc in 100-g, 154-kcal or 420-g, 919-kcal meals, or the concurrent emptying of 1-mm vs. larger spheres. One-millimeter spheres emptied consistently (p less than 0.01, paired t-test) faster than 2.4- or 3.2-mm spheres when ingested together with either the 420- or 100-g meals. Thus, in the 1-3-mm range of diameters, sphere size was a more important determinant of sphere emptying than meal size. Statistical analyses indicated that spheres 1.4 +/- 0.3 mm in diameter with a density of 1 empty at the same rate as 99mTc-liver. Our data indicate some commercially marketed microspheres of pancreatin will empty too slowly to be effective in digestion of food.
Authors:
J H Meyer; J Elashoff; V Porter-Fink; J Dressman; G L Amidon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Gastroenterology     Volume:  94     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1315-25     Citation Subset:  AIM; IM; S    
Affiliation:
Veterans Administration Medical Center, Sepulveda, California.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Animals
Dogs
Female
Food*
Gastric Emptying*
Humans
Indium Radioisotopes / diagnostic use
Male
Microspheres
Middle Aged
Pancreatin / physiology*
Particle Size
Stomach / physiology,  radionuclide imaging
Technetium / diagnostic use
Chemical
Reg. No./Substance:
0/Indium Radioisotopes; 7440-26-8/Technetium; 8049-47-6/Pancreatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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