Document Detail


Human posterior parietal cortex flexibly determines reference frames for reaching based on sensory context.
MedLine Citation:
PMID:  21092865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Current models of sensorimotor transformations emphasize the dominant role of gaze-centered representations for reach planning in the posterior parietal cortex (PPC). Here we exploit fMRI repetition suppression to test whether the sensory modality of a target determines the reference frame used to define the motor goal in the PPC and premotor cortex. We show that when targets are defined visually, the anterior precuneus selectively encodes the motor goal in gaze-centered coordinates, whereas the parieto-occipital junction, Brodman Area 5 (BA 5), and PMd use a mixed gaze- and body-centered representation. In contrast, when targets are defined by unseen proprioceptive cues, activity in these areas switches to represent the motor goal predominantly in body-centered coordinates. These results support computational models arguing for flexibility in reference frames for action according to sensory context. Critically, they provide neuroanatomical evidence that flexibility is achieved by exploiting a multiplicity of reference frames that can be expressed within individual areas.
Authors:
Pierre-Michel Bernier; Scott T Grafton
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuron     Volume:  68     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  776-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Psychology, Brain Imaging Center, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Male
Movement / physiology*
Parietal Lobe / physiology*
Photic Stimulation / methods*
Proprioception / physiology*
Psychomotor Performance / physiology*
Space Perception / physiology*
Young Adult
Grant Support
ID/Acronym/Agency:
NS44393/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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