Document Detail


Human and porcine insulins are equally effective in the regulation of glucose kinetics of diabetic patients during exercise.
MedLine Citation:
PMID:  6393677     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rate of hepatic glucose production (Ra) and peripheral utilization (Rd) was determined in 8 insulin-dependent diabetic subjects in basal state and during 40 min cycle ergometric exercise. The patients were treated with continuous sc infusion of either semisynthetic human or porcine (Actrapid) insulin. Basal rate of glucose production was comparable during human (2.29 +/- 0.19 mg/kg/min) and porcine (2.18 +/- 0.12 mg/kg/min) insulin therapy. In response to exercise, Ra rose 30 to 40% (P less than 0.05), to 2.85 +/- 0.35 vs 3.18 +/- 0.42 mg/kg/min, similarly during both studies. The peak rise in Rd (to 3.20 +/- 0.32 during human vs 3.78 +/- 0.44 mg/kg/min during porcine insulin) was comparable in both groups and not significantly different from the rise in Ra. Consequently, blood glucose levels remained unchanged. During the exercise tests, the metabolic conditions were stable and comparable in both studies, as indicated by similar levels of blood glucose, plasma free insulin HbA1, serum lipids and insulin binding to erythrocytes. In conclusion, semisynthetic human insulin is equally effective as porcine insulin in regulating glucose kinetics in the basal state and during exercise.
Authors:
V A Koivisto; R Pelkonen; E A Nikkilä; L G Heding
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta endocrinologica     Volume:  107     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  500-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Blood Glucose / analysis
Cholesterol / blood
Delayed-Action Preparations
Diabetes Mellitus, Type 1 / drug therapy,  metabolism*
Glucose / metabolism*
Growth Hormone / blood
Hemoglobin A, Glycosylated / blood
Humans
Insulin / blood,  therapeutic use*
Liver / metabolism
Male
Physical Exertion*
Swine
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Delayed-Action Preparations; 0/Hemoglobin A, Glycosylated; 0/Triglycerides; 11061-68-0/Insulin; 50-99-7/Glucose; 57-88-5/Cholesterol; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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