Document Detail

Human population structure and the adaptive response to pathogen-induced selection pressures.
MedLine Citation:
PMID:  22312055     Owner:  NLM     Status:  MEDLINE    
The past few years of research in human evolutionary genetics have provided novel insights and questions regarding how human adaptations to recent selective pressures have taken place. Here, we review the advances most relevant to understanding human evolution in response to pathogen-induced selective pressures. Key insights come from theoretical models of adaptive evolution, particularly those that consider spatially structured populations, and from empirical population genomic studies of adaptive evolution in humans. We also review the CCR5-Δ32 HIV resistance allele as a case study of pathogen resistance in humans. Taken together, the results make clear that the human response to pathogen-induced selection pressures depends on a complex interplay between the age of the pathogen, the genetic basis of potential resistance phenotypes, and how population structure impacts the adaptive process in humans.
John Novembre; Eunjung Han
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Philosophical transactions of the Royal Society of London. Series B, Biological sciences     Volume:  367     ISSN:  1471-2970     ISO Abbreviation:  Philos. Trans. R. Soc. Lond., B, Biol. Sci.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-07     Completed Date:  2012-05-21     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7503623     Medline TA:  Philos Trans R Soc Lond B Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  878-86     Citation Subset:  IM    
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA.
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MeSH Terms
Adaptation, Biological / genetics*
Disease Resistance / genetics*
Genetics, Population / methods*
Host-Pathogen Interactions / genetics*
Models, Genetic*
Receptors, CCR5 / genetics*
Selection, Genetic*
Grant Support
Reg. No./Substance:
0/Receptors, CCR5

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