| Human population structure and the adaptive response to pathogen-induced selection pressures. | |
| | |
MedLine Citation:
|
PMID: 22312055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The past few years of research in human evolutionary genetics have provided novel insights and questions regarding how human adaptations to recent selective pressures have taken place. Here, we review the advances most relevant to understanding human evolution in response to pathogen-induced selective pressures. Key insights come from theoretical models of adaptive evolution, particularly those that consider spatially structured populations, and from empirical population genomic studies of adaptive evolution in humans. We also review the CCR5-Δ32 HIV resistance allele as a case study of pathogen resistance in humans. Taken together, the results make clear that the human response to pathogen-induced selection pressures depends on a complex interplay between the age of the pathogen, the genetic basis of potential resistance phenotypes, and how population structure impacts the adaptive process in humans. |
| | |
Authors:
|
John Novembre; Eunjung Han |
Related Documents
:
|
15371565 - Naturally occurring intrauterine growth retardation and adult blood pressure in rats. 21058045 - The dash diet and insulin sensitivity. 17950095 - Hypoadiponectinemia is associated with blood pressure increase in obese insulin-resista... 3375905 - Cardiovascular and respiratory effects of oral premedication with trimeprazine and drop... 18731825 - Surgical decompression of the bowel in peritonitis. 3741825 - Intravenous lignocaine pretreatment to prevent intraocular pressure rise following suxa... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
|
Title: Philosophical transactions of the Royal Society of London. Series B, Biological sciences Volume: 367 ISSN: 1471-2970 ISO Abbreviation: Philos. Trans. R. Soc. Lond., B, Biol. Sci. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-07 Completed Date: 2012-05-21 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 7503623 Medline TA: Philos Trans R Soc Lond B Biol Sci Country: England |
Other Details:
|
Languages: eng Pagination: 878-86 Citation Subset: IM |
Affiliation:
|
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA. jnovembre@ucla.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Biological
/
genetics* Demography Disease Resistance / genetics* Genetics, Population / methods* Host-Pathogen Interactions / genetics* Humans Models, Genetic* Receptors, CCR5 / genetics* Selection, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
|
5T32AI007370/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, CCR5 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genome-wide scans provide evidence for positive selection of genes implicated in Lassa fever.
Next Document: Host genetics and population structure effects on parasitic disease.