Document Detail


Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease.
MedLine Citation:
PMID:  15104661     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Alloimmune incompatibility in allo-geneic stem cell transplantation (ASCT), pregnancy, and blood transfusion might trigger an immune response with clinical consequences. Human PLT antigens (HPAs), which play a significant role in pregnancy or blood transfusion-associated alloimmune thrombocytopenia, are also expressed on the surface of tissues affected by GVHD. Thus, HPA mismatch in HLA-identical ASCT could play a potential role in PLT engraftment and GVHD. STUDY DESIGN AND METHODS: We studied the HPA-1, -2, and -5 genotypes in Caucasian donors and patients involved in 77 HLA-identical ASCTs. We evaluated the association of HPA compatibility with clinical outcome, analyzing the relevance of host-versus-donor HPA incompatibility in PLT engraftment and donor-versus-host HPA incompatibility in GVHD. RESULTS: PLT engraftment and transfusion require-ments were similar in HPA-compatible and HPA-incompatible ASCT. Cases with severe thrombocytopenia or significant delayed PLT engraftment did not display host-versus-donor HPA incompatibility. Moreover, the incidence of GVHD did not correlate with HPA compatibility. CONCLUSION: Our results support no role for these antigens in immune complications of ASCT: PLT engraftment, requirement of PLT transfusions, and GVHD.
Authors:
M D García-Malo; J Corral; M González; C Solano; R González-Conejero; M D Caballero; R Pérez; J M Moraleda; V Vicente
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transfusion     Volume:  44     ISSN:  0041-1132     ISO Abbreviation:  Transfusion     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-23     Completed Date:  2004-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  771-6     Citation Subset:  IM    
Affiliation:
University of Murcia, Department of Medicine, Murcia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antigens, Human Platelet / analysis,  immunology*
Female
Graft vs Host Disease / etiology*
Humans
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation / adverse effects*
Platelet Transfusion*
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Antigens, Human Platelet

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