| Human platelet antigen systems in allogeneic peripheral blood progenitor cell transplantation: effect of human platelet antigen mismatch on platelet engraftment and graft-versus-host disease. | |
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MedLine Citation:
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PMID: 15104661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Alloimmune incompatibility in allo-geneic stem cell transplantation (ASCT), pregnancy, and blood transfusion might trigger an immune response with clinical consequences. Human PLT antigens (HPAs), which play a significant role in pregnancy or blood transfusion-associated alloimmune thrombocytopenia, are also expressed on the surface of tissues affected by GVHD. Thus, HPA mismatch in HLA-identical ASCT could play a potential role in PLT engraftment and GVHD. STUDY DESIGN AND METHODS: We studied the HPA-1, -2, and -5 genotypes in Caucasian donors and patients involved in 77 HLA-identical ASCTs. We evaluated the association of HPA compatibility with clinical outcome, analyzing the relevance of host-versus-donor HPA incompatibility in PLT engraftment and donor-versus-host HPA incompatibility in GVHD. RESULTS: PLT engraftment and transfusion require-ments were similar in HPA-compatible and HPA-incompatible ASCT. Cases with severe thrombocytopenia or significant delayed PLT engraftment did not display host-versus-donor HPA incompatibility. Moreover, the incidence of GVHD did not correlate with HPA compatibility. CONCLUSION: Our results support no role for these antigens in immune complications of ASCT: PLT engraftment, requirement of PLT transfusions, and GVHD. |
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Authors:
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M D García-Malo; J Corral; M González; C Solano; R González-Conejero; M D Caballero; R Pérez; J M Moraleda; V Vicente |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transfusion Volume: 44 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-23 Completed Date: 2004-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 771-6 Citation Subset: IM |
Affiliation:
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University of Murcia, Department of Medicine, Murcia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antigens, Human Platelet / analysis, immunology* Female Graft vs Host Disease / etiology* Humans Male Middle Aged Peripheral Blood Stem Cell Transplantation / adverse effects* Platelet Transfusion* Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Human Platelet |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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