| Human plasma triglyceride labeling after high sucrose feeding. II. Study on triglyceride kinetics and postheparin lipolytic activity. | |
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MedLine Citation:
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PMID: 165366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Kinetic studies of the very-low-density lipoprotein triglycerides (VLDL-TG) turnover by endogenous labeling with glycerol-2-3-H were performed in 13 patients in the postabsorptive state, first after 10-14 days on a low-sucrose high-starch diet, then again after 10-14 days of isocaloric high-sucrose low-starch diet (HSD). After HSD, a significant decrease in the fractional turnover rates of VLDL-TG was observed, as well as a modest but significant increase in its pool size, but the net turnover rates remained unchanged. Using Michaelis-Menten formulation, we have further calculated the Vmax and Km's of the removal system for VLDL-TG and found that the Vmax and Km's do not differ significantly between the two dietary periods. These results suggest that the removal mechanism for VLDL-TG has not changed after 10-14 days on the HSD, at least when the patients are studied in the postabsorptive state. Measurements of postheparin lipolytic acitivty under fed condition in 17 patients (including the 13 patients above) have shown a decrease after HSD. However, a defect in the removal of plasma-TG related to decreased activity of tissue-lipoprotein lipase in the fed state has not been conclusively uncovered by the kinetic studies performed in the postabsorptive state, and cannot contribute significantly to the expansion of VLDL-TG pool. |
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Authors:
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C H Wu; W W Shreeve |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 24 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1975 Jun |
Date Detail:
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Created Date: 1975-08-07 Completed Date: 1975-08-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 755-66 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calorimetry Cholesterol / blood Dietary Carbohydrates* Fasting Female Heparin / pharmacology* Humans Kinetics Lipid Mobilization / drug effects* Lipoprotein Lipase / metabolism Lipoproteins, VLDL / blood* Male Middle Aged Obesity / blood Starch / pharmacology Sucrose / pharmacology* Time Factors Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-50-1/Sucrose; 57-88-5/Cholesterol; 9005-25-8/Starch; 9005-49-6/Heparin; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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