Document Detail

Human plasma protein Z antigen: range in normal subjects and effect of warfarin therapy.
MedLine Citation:
PMID:  3580568     Owner:  NLM     Status:  MEDLINE    
In contrast to the other well-studied vitamin K-dependent proteins that circulate in plasma, protein Z antigen is much more variable. The concentration in plasmas collected in EDTA from 455 normal, healthy donors is normally distributed with a mean of 2.9 micrograms/mL (46 nmol/L) and a SD of 1.0 microgram/mL (95% interval of 32% to 168% of the mean). No significant correlation to age or sex could be detected. In comparison, the concentration of protein C antigen measured with the same type of assay on the same 455 samples has a log normal distribution with a mean of 4.0 micrograms/mL (65 nmol/L) and a 95% interval of 70% to 138% of the mean. Also in marked contrast to other plasma vitamin K-dependent proteins, the total protein Z antigen level is extremely low in patients on stable warfarin therapy (range 1% to 16% of normal). Moreover, even though greater than 95% of the antigen in normal plasmas adsorbs to barium citrate (a crude reflection of the presence of gamma-carboxyglutamic acid (Gla) residues), in the patients taking warfarin almost all of the small amount of the antigen failed to adsorb, suggesting that virtually no protein Z had its full complement of Gla residues. Total protein C antigen in the same 25 patients averaged 53% of normal (34% to 72%) and 54% (average) of the total remaining antigen still adsorbed to barium citrate. The concentration of protein Z antigen in the plasma of a normal individual given a loading dose of warfarin fell at an initial rate of approximately 20% a day, indicating a plasma half-life (t1/2) of 2 to 3 days.
J P Miletich; G J Broze
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  69     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-07     Completed Date:  1987-07-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1580-6     Citation Subset:  AIM; IM    
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MeSH Terms
Antibodies, Monoclonal / isolation & purification
Antigens / analysis*
Blood Proteins / immunology*
Protein C / analysis
Reference Values
Warfarin / therapeutic use*
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens; 0/Blood Proteins; 0/Protein C; 0/plasma protein Z; 81-81-2/Warfarin

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