Document Detail

Human plasma ghrelin levels increase during a one-year exercise program.
MedLine Citation:
PMID:  15585547     Owner:  NLM     Status:  MEDLINE    
Weight loss resulting from decreased caloric intake raises levels of the orexigenic hormone, ghrelin. Because ingested nutrients suppress ghrelin, increased ghrelin levels in hypophagic weight loss may result from decreased inhibitory input by ingested food, rather than from lost weight. We assessed whether ghrelin levels increase in response to exercise-induced weight loss without decreased caloric intake. We randomized 173 sedentary, overweight, postmenopausal women to an aerobic exercise intervention or stretching control group. At baseline, 3 months, and 12 months, we measured body weight and composition, food intake, cardiopulmonary fitness (maximal oxygen consumption), leptin, insulin, and ghrelin. Complete data were available for 168 women (97%) at 12 months. Exercisers lost 1.4 +/- 0.4 kg (P < 0.05 compared with baseline; P = 0.01 compared with stretchers) and manifested a significant, progressive increase in ghrelin levels, whereas neither measure changed among stretchers. Ghrelin increased 18% in exercisers who lost more than 3 kg (P < 0.001). There was no change in caloric intake in either group and no effect on ghrelin of exercise per se independent of its impact on body weight. In summary, ghrelin levels increase with weight loss achieved without reduced food intake, consistent with a role for ghrelin in the adaptive response constraining weight loss and, thus, in long-term body weight regulation.
Karen E Foster-Schubert; Anne McTiernan; R Scott Frayo; Robert S Schwartz; Kumar B Rajan; Yutaka Yasui; Shelley S Tworoger; David E Cummings
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.     Date:  2004-12-07
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-03-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  820-5     Citation Subset:  AIM; IM    
Department of Medicine, Division of Metabolism, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA.
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MeSH Terms
Body Mass Index
Body Size
Body Weight
Diet, Reducing*
Energy Intake
Exercise / physiology*
Middle Aged
Peptide Hormones / blood*
Time Factors
Grant Support
AG-1094/AG/NIA NIH HHS; M01-RR-00037/RR/NCRR NIH HHS; R01-CA-69334/CA/NCI NIH HHS; R01-DK-61516/DK/NIDDK NIH HHS; T32-DK-007247/DK/NIDDK NIH HHS; T32-EF-07262//PHS HHS
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones

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