| Human placental norepinephrine transporter mRNA: expression and correlation with fetal condition at birth. | |
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MedLine Citation:
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PMID: 9089783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine the primary form of human placental norepinephrine transporter (hNET) mRNA expressed in the human placenta and to compare the level of expression in normal pregnancies and in pregnancies complicated by drug exposure or other forms of physiological derangement. We used the hNET cDNA to measure RNA extracted from placenta and examined placental RNA following complicated and uncomplicated pregnancies. To compare transporter expression and its relation to fetal condition at birth, umbilical arterial plasma catecholamine levels, umbilical arterial blood gases and placental transporter mRNA level were compared by linear regression analysis. Uncomplicated pregnancies had a higher level of placental norepinephrine transporter mRNA than complicated pregnancies. An inverse relationship between umbilical cord norepinephrine level and transporter expression was demonstrated. We conclude that placental transporter expression represents an important and newly described metabolic function of the placenta. Placental catecholamine clearance mediated via the placental NET may be important in the pathophysiology of disorders associated with placental dysfunction, impaired placental blood flow or intrauterine growth retardation. This may also explain the adverse effects of drugs, such as cocaine, which block catecholamine transport. |
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Authors:
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L Bzoskie; J Yen; Y T Tseng; L Blount; K Kashiwai; J F Padbury |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Placenta Volume: 18 ISSN: 0143-4004 ISO Abbreviation: Placenta Publication Date: 1997 Mar-Apr |
Date Detail:
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Created Date: 1997-06-10 Completed Date: 1997-06-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 205-10 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Harbor-UCLA Medical Center, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apgar Score Blotting, Northern Carrier Proteins / metabolism* Embryonic and Fetal Development* Female Humans Infant, Newborn Norepinephrine / metabolism* Norepinephrine Plasma Membrane Transport Proteins Placenta / metabolism* Pregnancy Pregnancy Complications / metabolism RNA, Messenger / biosynthesis* Symporters* |
| Grant Support | |
ID/Acronym/Agency:
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DA-07753/DA/NIDA NIH HHS; HD-07013/HD/NICHD NIH HHS; HD-29713/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Norepinephrine Plasma Membrane Transport Proteins; 0/RNA, Messenger; 0/SLC6A2 protein, human; 0/Symporters; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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